Higher-order chromatin structure in DSB induction, repair and misrepair

被引：108

作者：

Falk, Martin ^{[1
]}

Lukasova, Emilie ^{[1
]}

Kozubek, Stanislav ^{[1
]}

机构：

[1] Acad Sci Czech Republ, Inst Biophys, CS-61265 Brno, Czech Republic

来源：

MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH | 2010年 / 704卷 / 1-3期

关键词：

DNA double strand breaks; DSB repair; Higher-order chromatin structure; Nuclear organization; Radiosensitivity; DOUBLE-STRAND BREAKS; HISTONE H2AX PHOSPHORYLATION; FIELD GEL-ELECTROPHORESIS; HUMAN TRANSCRIPTOME MAP; DNA-DAMAGE RESPONSE; IONIZING-RADIATION; GAMMA-H2AX FOCI; GENOMIC INSTABILITY; HUMAN-CELLS; CHROMOSOME TERRITORIES;

D O I：

10.1016/j.mrrev.2010.01.013

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Double-strand breaks (DSBs), continuously introduced into DNA by cell metabolism, ionizing radiation and some chemicals, are the biologically most deleterious type of genome damage, and must be accurately repaired to protect genomic integrity, ensure cell survival, and prevent carcinogenesis. Although a huge amount of information has been published on the molecular basis and biological significance of DSB repair, our understanding of DSB repair and its spatiotemporal arrangement is still incomplete. In particular, the role of higher-order chromatin structure in DSB induction and repair, movement of DSBs and the mechanism giving rise to chromatin exchanges, and many other currently disputed questions are discussed in this review. Finally, a model explaining the formation of chromosome translocations is proposed. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：88 / 100

页数：13

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