Identification and cloning of a CD43-associated serine/threonine kinase

被引：9

作者：

Wang, WM

Link, V

Green, JM

机构：

[1] Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USA

[2] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA

来源：

CELLULAR IMMUNOLOGY | 2000年 / 205卷 / 01期

基金：

美国国家卫生研究院;

关键词：

CD43; leukosialin; sialophorin; serine/threonine kinase;

D O I：

10.1006/cimm.2000.1716

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

CD43 is expressed on most hematopoetic cells and has been shown to regulate the activation and adhesion of T cells. We have cloned a serine/threonine kinase that can interact with the cytoplasmic domain of CD43. This protein is expressed in multiple tissues, including lymphoid cells. Analysis of the subcellular localization reveals it to be present in both the nucleus and the cytoplasm of the cell. The identification of this protein suggests that CD43 may mediate its biologic effects through activation of a kinase cascade, resulting in the regulation of cell growth. (C) 2000 Academic Press.

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收藏

页码：34 / 39

页数：6

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