Rote of inducible nitric oxide synthase in resistance to Mycobacterium leprae in mice

被引：29

作者：

Adams, LB

Job, CK

Krahenbuhl, JL

机构：

[1] Louisiana State Univ, Lab Res Branch, Natl Hansens Dis Programs, Baton Rouge, LA 70894 USA

[2] St Thomas Hosp & Leprosy Ctr, Chettupattu TS DT 606801, Tamil Nadu, India

来源：

INFECTION AND IMMUNITY | 2000年 / 68卷 / 09期

关键词：

D O I：

10.1128/IAI.68.9.5462-5465.2000

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The manifestation of leprosy in humans is largely determined by host immunity to Mycobacterium leprae and is a model for immunoregulation in a human disease. However, animal models available for exploration of the leprosy spectrum are inadequate. This study explored M. leprae infection in mice deficient in inducible nitric oxide synthase, and this report describes elements resembling borderline tuberculoid leprosy in humans.

引用

页码：5462 / 5465

页数：4

共 21 条

[1]

ADAMS LB, 1991, J IMMUNOL, V147, P1642

[2]

Adams LB, 2000, INT J LEPROSY, V68, P1

[3] Comparison of the roles of reactive oxygen and nitrogen intermediates in the host response to Mycobacterium tuberculosis using transgenic mice [J].