Evidence for evolutionary conservation of sex-determining genes

被引:641
作者
Raymond, CS
Shamu, CE
Shen, MM
Seifert, KJ
Hirsch, B
Hodgkin, J
Zarkower, D [1 ]
机构
[1] Univ Minnesota, Sch Med, Inst Human Genet, Minneapolis, MN 55455 USA
[2] Univ Minnesota, Sch Med, Dept Biochem, Minneapolis, MN 55455 USA
[3] Univ Minnesota, Sch Med, Dept Lab Med & Pathol, Minneapolis, MN 55455 USA
[4] MRC, Mol Biol Lab, Cambridge CB2 2QH, England
关键词
D O I
10.1038/35618
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Most metazoans occur as two sexes. Surprisingly, molecular analyses have hitherto indicated that sex-determining mechanisms differ completely between phyla. Here we present evidence to the contrary, We have isolated the male sexual regulatory gene mab-3 (ref. 1) from the nematode Caenorhabditis elegans and found that it is related to the Drosophila melanogaster sexual regulatory gene doublesex (dsx)(2). Both genes encode proteins with a DNA-binding motif(3) that we have named the 'DM domain'. Both genes control sex-specific neuroblast differentiation and yolk protein gene transcription; dsx controls other sexually dimorphic features as well, The form of DSX that is found in males can direct male-specific neuroblast differentiation in C. elegans. This structural and functional similarity between phyla suggests a common evolutionary origin of at least some aspects of sexual regulation. We have identified a human gene, DMT1, that encodes a protein with a DM domain and find that DMT1 is expressed only in testis. DMT1 maps to the distal short arm of chromosome 9, a location implicated in human XY sex reversal(4). Proteins with DM domains may therefore also regulate sexual development in mammals.
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页码:691 / 695
页数:5
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