Association of interleukin-15 protein and interleukin-15 receptor genetic variation with resistance exercise training responses

被引:152
作者
Riechman, SE
Balasekaran, G
Roth, SM
Ferrell, RE
机构
[1] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Human Genet, Pittsburgh, PA 15260 USA
[2] Univ Maryland, Dept Kinesiol, College Pk, MD 20742 USA
关键词
IL-15; strength; skeletal muscle; muscle quality;
D O I
10.1152/japplphysiol.00491.2004
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Interleukin-15 (IL-15) is an anabolic cytokine that is produced in skeletal muscle and directly affects muscle anabolism in animal and in vitro models. The contribution of IL-15 variability in muscle responses to 10 wk of resistance exercise training in young men and women was examined by measuring acute and chronic changes in IL-15 protein in plasma and characterizing genetic variation in the IL-15 receptor-alpha gene ( IL15RA). Participants trained 3 days a week at 75% of one repetition maximum, performing three sets ( 6 - 10 repetitions) of 13 resistance exercises. Plasma IL-15 protein was significantly increased ( P < 0.05) immediately after acute resistance exercise but did not change with training and was not associated with variability in muscle responses with training. A single nucleotide polymorphism in exon 7 of IL15RA was strongly associated with muscle hypertrophy and accounted for 7.1% of the variation in regression modeling. A polymorphism in exon 4 was also independently associated with muscle hypertrophy and accounted for an additional 3.5% of the variation in hypertrophy. These results suggest that IL-15 is an important mediator of muscle mass response to resistance exercise training in humans and that genetic variation in IL15RA accounts for a significant proportion of the variability in this response.
引用
收藏
页码:2214 / 2219
页数:6
相关论文
共 29 条
[1]   GOLD - Graphical Overview of Linkage Disequilibrium [J].
Abecasis, GR ;
Cookson, WOC .
BIOINFORMATICS, 2000, 16 (02) :182-183
[2]  
ANDERSON DM, 1995, J BIOL CHEM, V270, P29862
[3]   Interleukin-15 promotes angiogenesis in vivo [J].
Angiolillo, AL ;
Kanegane, H ;
Sgadari, C ;
Reaman, GH ;
Tosato, G .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1997, 233 (01) :231-237
[4]   RETRACTED: Death deflected:: IL-15 inhibits TNF-α-mediated apoptosis in fibroblasts by TRAF2 recruitment to the IL-15Rα chain (Retracted Article. See vol 25, pg 1118, 2011) [J].
Bulfone-Paus, S ;
Bulanova, E ;
Pohl, T ;
Budagian, V ;
Dürkop, H ;
Rückert, R ;
Kunzendorf, U ;
Paus, R ;
Krause, H .
FASEB JOURNAL, 1999, 13 (12) :1575-1585
[5]   Interleukin-15 protects from lethal apoptosis in vivo [J].
BulfonePaus, S ;
Ungureanu, D ;
Pohl, T ;
Lindner, G ;
Paus, R ;
Ruckert, R ;
Krause, H ;
Kunzendorf, U .
NATURE MEDICINE, 1997, 3 (10) :1124-1128
[6]   Interleukin-15 antagonizes muscle protein waste in tumour-bearing rats [J].
Carbo, N. ;
Lopez-Soriano, J. ;
Costelli, P. ;
Busquets, S. ;
Alvarez, B. ;
Baccino, F. M. ;
Quinn, L. S. ;
Lopez-Soriano, F. J. ;
Argiles, J. M. .
BRITISH JOURNAL OF CANCER, 2000, 83 (04) :526-531
[7]   TNFα inhibits skeletal myogenesis through a PW1-dependent pathway by recruitment of caspase pathways [J].
Coletti, D ;
Yang, E ;
Marazzi, G ;
Sassoon, D .
EMBO JOURNAL, 2002, 21 (04) :631-642
[8]   The role of tumor necrosis factor-alpha (TNF-α) in skeletal muscle regeneration:: Studies in TNF-α(-/-) and TNF-α(-/-)/LT-α(-/-) mice [J].
Collins, RA ;
Grounds, MD .
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 2001, 49 (08) :989-1001
[9]   Natural splicing of exon 2 of human interleukin-15 receptor α-chain mRNA results in a shortened form with a distinct pattern of expression [J].
Dubois, S ;
Magrangeas, F ;
Lehours, P ;
Raher, S ;
Bernard, J ;
Boisteau, O ;
Leroy, S ;
Minvielle, S ;
Godard, A ;
Jacques, Y .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (38) :26978-26984
[10]   IL-15, A NOVEL T-CELL GROWTH-FACTOR THAT SHARES ACTIVITIES AND RECEPTOR COMPONENTS WITH IL-2 [J].
GIRI, JG ;
ANDERSON, DM ;
KUMAKI, S ;
PARK, LS ;
GRABSTEIN, KH ;
COSMAN, D .
JOURNAL OF LEUKOCYTE BIOLOGY, 1995, 57 (05) :763-766