Anticonvulsant medications extend worm life-span

被引：149

作者：

Evason, K ^{[1
]}

Huang, C ^{[1
]}

Yamben, I ^{[1
]}

Covey, DF ^{[1
]}

Kornfeld, K ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Dept Mol Biol & Pharmacol, St Louis, MO 63110 USA

来源：

SCIENCE | 2005年 / 307卷 / 5707期

关键词：

D O I：

10.1126/science.1105299

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Genetic studies have elucidated mechanisms that regulate aging, but there has been little progress in identifying drugs that delay aging. Here, we report that ethosuximide, trimethadione, and 3,3-diethyl-2-pyrrolidinone increase mean and maximum life-span of Caenorhabditis elegans and delay age-related declines of physiological processes, indicating that these compounds retard the aging process. These compounds, two of which are approved for human use, are anticonvulsants that modulate neural activity. These compounds also regulated neuromuscular activity in nematodes. These findings suggest that the life-span-extending activity of these compounds is related to the anticonvulsant activity and implicate neural activity in the regulation of aging.

引用

页码：258 / 262

页数：5

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