Breast cancer chemoresistance: Emerging importance of cancer stem cells

被引：132

作者：

Chuthapisith, Suebwong ^{[1
]}

Eremin, Jennifer ^{[2
]}

El-Sheemey, Mohamed ^{[2
,3
]}

Eremin, Oleg ^{[2
,4
]}

机构：

[1] Mahidol Univ, Siriraj Hosp, Fac Med, Dept Surg, Bangkok 10700, Thailand

[2] Lincoln Cty Hosp, Dept Res & Dev, Lincoln, England

[3] Lincoln Univ, Fac Hlth Life & Social Sci, Dept Forens & Biomed Sci, Lincoln, England

[4] Queens Med Ctr, Dept Surg, Nottingham NG7 2UH, England

来源：

SURGICAL ONCOLOGY-OXFORD | 2010年 / 19卷 / 01期

关键词：

Cancer stem cells; Breast cancer; Chemoresistance; BONE-MARROW; BIOLOGY; LEUKEMIA; GEFITINIB; RESISTANT; THERAPY;

D O I：

10.1016/j.suronc.2009.01.004

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Cancer stem cells (CSCs) have recently been documented in solid tumours. Evidence has suggested that CSCs are involved in carcinogenesis, tumour invasion and metastases, and resistance to various forms of therapies, including chemotherapy. Breast CSCs are characterised by the expression of CD44 but lack of CD24 (CD44(+)/CD24(-) cells). The mechanisms involved in chemoresistance of breast CSCs are complex and not clearly defined. Overexpression of ABC transporters, detoxification enzymes (aldehyde dehydrogenase), low cell turn over rate and the ability to activate the DNA check point response are possibly all involved. Innovative therapies, based on a better understanding of CSCs, should lead to enhanced and tong-term cure rates in breast cancer. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：27 / 32

页数：6

共 47 条

[1]

Abraham BK, 2005, CLIN CANCER RES, V11, P1154

[2]

Prospective identification of tumorigenic breast cancer cells [J].