Synthesis of 4-arylaminoquinazolines and 2-aryl-4-arylaminoquinazolines from 2-aminobenzonitrile, anilines and formic acid or benzaldehydes

被引：60

作者：

Szczepankiewicz, W ^{[1
]}

Suwinski, J ^{[1
]}

Bujok, R ^{[1
]}

机构：

[1] Silesian Univ Technol, Inst Organ Chem & Technol, PL-44100 Gliwice, Poland

来源：

TETRAHEDRON | 2000年 / 56卷 / 47期

关键词：

o-aminobenzonitrile; amidines; acidity; quinazolines; synthesis;

D O I：

10.1016/S0040-4020(00)00899-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2-Aminobenzonitrile treated with anilines in the presence of aluminium chloride gave respective 2-amino-N-arylbenzamidines. 4-Arylaminoquinazolines lacking a substituent at the 2 position were obtained directly by heating 2-amino-N-arylbenzamidines in formic acid; in similar conditions other carboxylic acids did not react with the amidines. The latter when treated with aidehydes afforded 2-aryl-4arylimino-1H-2,3-dihydroquinazolines readily oxidizable by potassium permanganate to 2-aryl-4-arylaminoquinazolines. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：9343 / 9349

页数：7

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