Megalospermatocytes in the human testis exhibit asynapsis of chromosomes

被引：4

作者：

Johannisson, R

Schulze, W

Holstein, AF

机构：

[1] Univ Hamburg, Dept Androl, Hamburg, Germany

[2] Univ Hamburg, Dept Microscop Anat, Hamburg, Germany

[3] Univ Lubeck, Inst Pathol, Lubeck, Germany

来源：

ANDROLOGIA | 2003年 / 35卷 / 03期

关键词：

asynapsis; megalospermatocytes; meiosis; human spermatogenesis;

D O I：

10.1046/j.1439-0272.2003.00551.x

中图分类号：

R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

摘要：

Testis biopsies of three infertile patients were identified, which showed a predomination of megalospermatocytes in the seminiferous tubules. Megalospermatocytes are very large primary spermatocytes indicating a spermatogenic arrest. Because of the high percentage of these germ cells it was possible to apply a whole-mount spreading technique to investigate the chromosomal pairing behaviour in prophase I of meiosis. It could be shown that most of the megalospermatocytes exhibited extensive chromosomal asynapsis, suggesting that a characteristic meiotic disorder may give rise to reduced fertility, or even infertility.

引用

页码：146 / 151

页数：6

共 29 条

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