Endothelins in chronic diabetic complications

被引：53

作者：

Khan, ZA

Chakrabarti, S ^{[1
]}

机构：

[1] Univ Western Ontario, Dept Pathol, London, ON N6A 5C1, Canada

[2] Univ Western Ontario, Dept Microbiol, London, ON N6A 5C1, Canada

[3] Univ Western Ontario, Dept Immunol, London, ON N6A 5C1, Canada

[4] Univ Western Ontario, Dept Pathol, London, ON N6A 5C1, Canada

来源：

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY | 2003年 / 81卷 / 06期

关键词：

endothelins; diabetic complications; retinopathy; nephropathy; neuropathy; cardiomyopathy;

D O I：

10.1139/Y03-053

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Endothelins are widely distributed in the body and perform several vascular and nonvascular functions. Experimental data indicate abnormalities of the endothelin system in several organs affected in chronic diabetic complications. In support of this notion, it has been shown that endothelin-receptor antagonists prevent structural and functional abnormalities in target organs of diabetic complications in animal models. Alterations of plasma endothelin levels have also been demonstrated in human diabetes. This review discusses the role of endothelins in the pathogenesis of chronic diabetic complications. The current experimental evidence suggests that endothelin-receptor antagonism may potentially be an adjuvant therapeutic tool in the treatment of chronic diabetic complications.

引用

页码：622 / 634

页数：13

共 158 条

[1] The relation between plasma endothelin-1 levels and metabolic control, risk factors, treatment modalities, and diabetic microangiopathy in patients with Type 2 diabetes mellitus [J].

Ak, G ;

Buyukberber, S ;

Sevinc, A ;

Turk, HM ;

Ates, M ;

Sari, R ;

Savli, H ;

Cigli, A .

JOURNAL OF DIABETES AND ITS COMPLICATIONS, 2001, 15 (03) :150-157

[2]

ANDERSEN AR, 1983, DIABETOLOGIA, V25, P496

[3] INSULIN INFLUENCES IMMUNOREACTIVE ENDOTHELIN RELEASE BY HUMAN VASCULAR SMOOTH-MUSCLE CELLS [J].

ANFOSSI, G ;

CAVALOT, F ;

MASSUCCO, P ;

MATTIELLO, L ;

MULARONI, E ;

HAHN, A ;

TROVATI, M .

METABOLISM-CLINICAL AND EXPERIMENTAL, 1993, 42 (09) :1081-1083

[4] CLONING AND EXPRESSION OF A CDNA-ENCODING AN ENDOTHELIN RECEPTOR [J].

ARAI, H ;

HORI, S ;

ARAMORI, I ;

OHKUBO, H ;

NAKANISHI, S .

NATURE, 1990, 348 (6303) :730-732

[5]

ARAI K, 1987, J BIOL CHEM, V262, P16969

[6]

ARAMORI I, 1992, J BIOL CHEM, V267, P12468

[7] REGULATION OF ENDOTHELIN-1 BIOSYNTHESIS [J].

BENATTI, L ;

FABBRINI, MS ;

PATRONO, C .

PLATELET-DEPENDENT VASCULAR OCCLUSION, 1994, 714 :109-121

[8] Endothelin antagonists and renal protection [J].

Benigni, A ;

Perico, N ;

Remuzzi, G .

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 2000, 35 :S75-S78

[9]

Blakesley Vicky A., 1996, P824

[10]

Blom M L, 1994, Del Med J, V66, P379

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