Antinociceptive effects of morphine injected into the nucleus parafascicularis thalami of the rat

被引:26
作者
Harte, SE [1 ]
Lagman, AL [1 ]
Borszcz, GS [1 ]
机构
[1] Wayne State Univ, Dept Psychol, Detroit, MI 48202 USA
关键词
medial thalamus; parafascicularis; nociception; vocalization; morphine; methylnaloxonium;
D O I
10.1016/S0006-8993(00)02583-X
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The antinociceptive action of morphine microinjected into the nucleus parafascicularis thalami (nPf) on pain behaviors organized at different levels of the neuraxis was examined in the rat. Behaviors organized at spinal (spinal motor reflexes, SMRs), medullary (vocalizations during shock,VDSs), and forebrain (vocalization afterdischarges, VADs) levels were elicited by noxious tailshock. Morphine administered into nPf generated dose-dependent increases in thresholds of VDS and VAD, but failed to elevate SMR thresholds. Increases in vocalization thresholds were reversed in a dose-dependent manner by the microinjection of the mu-opiate receptor antagonist, methylnaloxonium, into nPf. Results are discussed in terms of the relative influence of nPf-administered morphine on nociceptive processing at spinal versus supraspinal levels of the neuraxis. (C) 2000 Published by Elsevier Science B.V.
引用
收藏
页码:78 / 86
页数:9
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