The pathogenesis of atherosclerosis

被引:28
作者
Schachter, M [1 ]
机构
[1] St Marys Hosp, Imperial Coll, Sch Med, Dept Clin Pharmacol, London W2 1NY, England
关键词
atherosclerosis; smooth muscle cells; growth factors;
D O I
10.1016/S0167-5273(97)00235-0
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The hypothesis that atherosclerosis is a 'response to injury' is now generally accepted. This paper briefly reviews factors that can damage the vascular endothelium plus the formation of fatty streak lesions, thrombogenic surfaces, fibrous plaques and complex advanced lesions of atherosclerosis. (C) 1997 Elsevier Science Ireland Ltd.
引用
收藏
页码:S3 / S7
页数:5
相关论文
共 32 条
  • [1] PROLIFERATIVE AND CYTOTOXIC EFFECTS OF MILDLY OXIDIZED LOW-DENSITY LIPOPROTEINS ON VASCULAR SMOOTH-MUSCLE CELLS
    AUGE, N
    PIERAGGI, MT
    THIERS, JC
    NEGRESALVAYRE, A
    SALVAYRE, R
    [J]. BIOCHEMICAL JOURNAL, 1995, 309 : 1015 - 1020
  • [2] BENDITT EP, 1977, AM J PATHOL, V86, P693
  • [3] ATHEROSCLEROSIS - BASIC MECHANISMS - OXIDATION, INFLAMMATION, AND GENETICS
    BERLINER, JA
    NAVAB, M
    FOGELMAN, AM
    FRANK, JS
    DEMER, LL
    EDWARDS, PA
    WATSON, AD
    LUSIS, AJ
    [J]. CIRCULATION, 1995, 91 (09) : 2488 - 2496
  • [4] CALCIUM-CHANNEL ANTAGONISTS FOR PREVENTION OF ATHEROSCLEROSIS
    BORCHERDING, SM
    MEEVES, SG
    KLUTMAN, NE
    HOWARD, PA
    [J]. ANNALS OF PHARMACOTHERAPY, 1993, 27 (01) : 61 - 67
  • [5] CATHCART MK, 1991, J LIPID RES, V32, P63
  • [6] THE ROLE OF NITRIC-OXIDE AND OTHER ENDOTHELIUM-DERIVED VASOACTIVE SUBSTANCES IN VASCULAR-DISEASE
    COHEN, RA
    [J]. PROGRESS IN CARDIOVASCULAR DISEASES, 1995, 38 (02) : 105 - 128
  • [7] Gimbrone M A Jr, 1976, Prog Hemost Thromb, V3, P1
  • [8] BINDING-SITE ON MACROPHAGES THAT MEDIATES UPTAKE AND DEGRADATION OF ACETYLATED LOW-DENSITY LIPOPROTEIN, PRODUCING MASSIVE CHOLESTEROL DEPOSITION
    GOLDSTEIN, JL
    HO, YK
    BASU, SK
    BROWN, MS
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1979, 76 (01) : 333 - 337
  • [9] HIGH-DENSITY LIPOPROTEIN CHOLESTEROL AND CARDIOVASCULAR-DISEASE - 4 PROSPECTIVE AMERICAN-STUDIES
    GORDON, DJ
    PROBSTFIELD, JL
    GARRISON, RJ
    NEATON, JD
    CASTELLI, WP
    KNOKE, JD
    JACOBS, DR
    BANGDIWALA, S
    TYROLER, HA
    [J]. CIRCULATION, 1989, 79 (01) : 8 - 15
  • [10] IMMUNE-MECHANISMS IN ATHEROSCLEROSIS
    HANSSON, GK
    JONASSON, L
    SEIFERT, PS
    STEMME, S
    [J]. ARTERIOSCLEROSIS, 1989, 9 (05): : 567 - 578