Methyloxime-substituted aminopyrrolidine: A new surrogate for 7-basic group of quinolone

被引：16

作者：

Hong, CY ^{[1
]}

Kim, YK ^{[1
]}

Lee, YH ^{[1
]}

Kwak, JH ^{[1
]}

机构：

[1] Biotech Res Inst, Taejon 305380, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 03期

关键词：

D O I：

10.1016/S0960-894X(97)10222-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Novel fluoroquinolones containing oxime functionalized aminopyrrolidines have been synthesized. They were found to possess potent antibacterial activities against both Gram-negative and Gram-positive organisms, including methicillin resistant Staphylococcus aureus (MRSA). Among these compounds, LB20277 (compound 12) showed the most favorable in vivo efficacy and pharmacokinetic profile in animals. Based on these promising results, LB20277 was selected as a candidate for further evaluation. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：221 / 226

页数：6

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