Brown Adipose Tissue Improves Whole-Body Glucose Homeostasis and Insulin Sensitivity in Humans

被引：603

作者：

Chondronikola, Maria ^{[1
,2
,3
,4
]}

Volpi, Elena ^{[3
,5
,6
,7
]}

Borsheim, Elisabet ^{[1
,8
]}

Porter, Craig ^{[1
,8
]}

Annamalai, Palam ^{[9
]}

Enerback, Sven ^{[10
]}

Lidell, Martin E. ^{[10
]}

Saraf, Manish K. ^{[1
,8
]}

Labbe, Sebastien M. ^{[11
]}

Hurren, Nicholas M. ^{[1
,8
]}

Yfanti, Christina ^{[1
,6
]}

Chao, Tony ^{[1
,2
,3
]}

Andersen, Clark R. ^{[1
,8
]}

Cesani, Fernando ^{[12
]}

Hawkins, Hal ^{[13
,14
]}

Sidossis, Labros S. ^{[1
,3
,4
,5
,6
,7
]}

机构：

[1] Shriners Hosp Children, Metab Unit, Galveston, TX 77550 USA

[2] Univ Texas Med Branch, Dept Prevent Med & Community Hlth, Galveston, TX 77555 USA

[3] Univ Texas Med Branch, Dept Nutr & Metab, Div Rehabil Sci, Galveston, TX 77555 USA

[4] Harokopio Univ Athens, Dept Nutr & Dietet, Athens, Greece

[5] Univ Texas Med Branch, Inst Translat Sci, Galveston, TX 77555 USA

[6] Univ Texas Med Branch, Sealy Ctr Aging, Galveston, TX 77555 USA

[7] Univ Texas Med Branch, Dept Internal Med, Galveston, TX 77555 USA

[8] Univ Texas Med Branch, Dept Surg, Galveston, TX 77555 USA

[9] Univ Texas Med Branch, Dept Intervent Radiol, Galveston, TX 77555 USA

[10] Univ Gothenburg, Sahlgrenska Acad, Inst Biomed, Dept Med & Clin Genet, Gothenburg, Sweden

[11] Quebec Heart & Lung Res Inst Ctr, Quebec City, PQ, Canada

[12] Univ Texas Med Branch, Dept Nucl Med, Galveston, TX 77555 USA

[13] Univ Texas Med Branch, Dept Pathol, Galveston, TX 77555 USA

[14] Shriners Hosp Children, Dept Pathol, Galveston, TX 77550 USA

来源：

DIABETES | 2014年 / 63卷 / 12期

基金：

瑞典研究理事会; 加拿大健康研究院; 美国国家卫生研究院;

关键词：

TYPE-2 DIABETIC SUBJECTS; FATTY-ACID-METABOLISM; COLD-EXPOSURE; ADULT HUMANS; RESISTANCE; THERMOGENESIS; ACTIVATION; REDUCTION; OXIDATION; EXERCISE;

D O I：

10.2337/db14-0746

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Brown adipose tissue (BAT) has attracted scientific interest as an antidiabetic tissue owing to its ability to dissipate energy as heat. Despite a plethora of data concerning the role of BAT in glucose metabolism in rodents, the role of BAT (if any) in glucose metabolism in humans remains unclear. To investigate whether BAT activation alters whole-body glucose homeostasis and insulin sensitivity in humans, we studied seven BAT-positive (BAT(+)) men and five BAT-negative (BAT(-)) men under thermoneutral conditions and after prolonged (5-8 h) cold exposure (CE). The two groups were similar in age, BMI, and adiposity. CE significantly increased resting energy expenditure, whole-body glucose disposal, plasma glucose oxidation, and insulin sensitivity in the BAT+ group only. These results demonstrate a physiologically significant role of BAT in whole-body energy expenditure, glucose homeostasis, and insulin sensitivity in humans, and support the notion that BAT may function as an antidiabetic tissue in humans.

引用

页码：4089 / 4099

页数：11

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