Endothelial dysfunction and angiogenesis impairment in the ageing vasculature

被引：312

作者：

Ungvari, Zoltan ^{[1
,2
,3
,4
,5
]}

Tarantini, Stefano ^{[1
,2
,3
,4
]}

Kiss, Tamas ^{[1
,2
,3
,4
]}

Wren, Jonathan D. ^{[1
,6
]}

Giles, Cory B. ^{[1
,6
]}

Griffin, Courtney T. ^{[7
]}

Murfee, Walter Lee ^{[8
]}

Pacher, Pal ^{[9
]}

Csiszar, Anna ^{[1
,2
,3
,4
]}

机构：

[1] Univ Oklahoma, Hlth Sci Ctr, Reynolds Oklahoma Ctr Aging, Oklahoma City, OK 73019 USA

[2] Univ Oklahoma, Hlth Sci Ctr, Dept Geriatr Med, Translat Gerosci Lab, Oklahoma City, OK 73019 USA

[3] Univ Szeged, Fac Med, Dept Med Phys & Informat, Szeged, Hungary

[4] Univ Szeged, Fac Sci & Informat, Szeged, Hungary

[5] Semmelweis Univ, Dept Pulmonol, Budapest, Hungary

[6] Oklahoma Med Res Fdn, Arthritis & Clin Immunol Res Program, 825 NE 13th St, Oklahoma City, OK 73104 USA

[7] Oklahoma Med Res Fdn, Cardiovasc Biol Res Program, Oklahoma City, OK 73104 USA

[8] Univ Florida, J Crayton Pruitt Family Dept Biomed Engn, Gainesville, FL USA

[9] NIAAA, Lab Cardiovasc Physiol & Tissue Injury, NIH, Bethesda, MD USA

来源：

NATURE REVIEWS CARDIOLOGY | 2018年 / 15卷 / 09期

关键词：

NITRIC-OXIDE SYNTHASE; KAPPA-B ACTIVATION; OXIDATIVE STRESS; PROGENITOR CELLS; GENE-EXPRESSION; GROWTH-FACTOR; POLY(ADP-RIBOSE) POLYMERASE-1; CALORIC RESTRICTION; DEPENDENT DILATION; HYDROGEN-SULFIDE;

D O I：

10.1038/s41569-018-0030-z

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Ageing is the main risk factor for the development of cardiovascular diseases. A central mechanism by which ageing promotes vascular pathologies is compromising endothelial health. The age-related attenuation of endothelium-dependent dilator responses (endothelial dysfunction) associated with impairment of angiogenic processes and the subsequent pathological remodelling of the microcirculation contribute to compromised tissue perfusion and exacerbate functional decline in older individuals. This Review focuses on cellular, molecular, and functional changes that occur in the endothelium during ageing. We explore the links between oxidative and nitrative stress and the conserved molecular pathways affecting endothelial dysfunction and impaired angiogenesis during ageing. We also speculate on how these pathological processes could be therapeutically targeted. An improved understanding of endothelial biology in older patients is crucial for all cardiologists because maintenance of a competently functioning endothelium is critical for adequate tissue perfusion and long-term cardiac health.

引用

页码：555 / 565

页数：11

共 155 条

[1] NAD(P)H oxidase-generated superoxide anion accounts for reduced control of myocardial O2 consumption by NO in old Fischer 344 rats [J].

Adler, A ;

Messina, E ;

Sherman, B ;

Wang, ZP ;

Huang, H ;

Linke, A ;

Hintze, TH .

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2003, 285 (03) :H1015-H1022

[2]

Ahluwalia A, 2011, J PHYSIOL PHARMACOL, V62, P583

[3] Poly(ADP-ribose) polymerase-1 regulates activation of activator protein-1 in murine fibroblasts [J].

Andreone, TL ;

O'Connor, M ;

Denenberg, A ;

Hake, PW ;

Zingarelli, B .

JOURNAL OF IMMUNOLOGY, 2003, 170 (04) :2113-2120

[4] EFFECTS OF AGING ON QUANTITATIVE STRUCTURAL-PROPERTIES OF CORONARY VASCULATURE AND MICROVASCULATURE IN RATS [J].

ANVERSA, P ;

LI, P ;

SONNENBLICK, EH ;

OLIVETTI, G .

AMERICAN JOURNAL OF PHYSIOLOGY, 1994, 267 (03) :H1062-H1073

[5] Peripheral vascular endothelial dysfunction and apoptosis in old monkeys [J].

Asai, K ;

Kudej, RK ;

Shen, YT ;

Yang, GP ;

Takagi, G ;

Kudej, AB ;

Geng, YJ ;

Sato, N ;

Nazareno, JB ;

Vatner, DE ;

Natividad, F ;

Bishop, SP ;

Vatner, SF .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2000, 20 (06) :1493-1499

[6] Defects in activation of nitric oxide synthases occur during delayed angiogenesis in aging [J].

Bach, MHM ;

Sadoun, E ;

Reed, MJ .

MECHANISMS OF AGEING AND DEVELOPMENT, 2005, 126 (04) :467-473

[7] Liver-Specific Knockdown of IGF-1 Decreases Vascular Oxidative Stress Resistance by Impairing the Nrf2-Dependent Antioxidant Response: A Novel Model of Vascular Aging [J].

Bailey-Downs, Lora C. ;

Mitschelen, Matthew ;

Sosnowska, Danuta ;

Toth, Peter ;

Pinto, John T. ;

Ballabh, Praveen ;

Valcarcel-Ares, M. Noa ;

Farley, Julie ;

Koller, Akos ;

Henthorn, Jim C. ;

Bass, Caroline ;

Sonntag, William E. ;

Ungvari, Zoltan ;

Csiszar, Anna .

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 2012, 67 (04) :313-329

[8] Age-Related Decline of Autocrine Pituitary Adenylate Cyclase-Activating Polypeptide Impairs Angiogenic Capacity of Rat Cerebromicrovascular Endothelial Cells [J].

Banki, Eszter ;

Sosnowska, Danuta ;

Tucsek, Zsuzsanna ;

Gautam, Tripti ;

Toth, Peter ;

Tarantini, Stefano ;

Tamas, Andrea ;

Helyes, Zsuzsanna ;

Reglodi, Dora ;

Sonntag, William E. ;

Csiszar, Anna ;

Ungvari, Zoltan .

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 2015, 70 (06) :665-674

[9] Are sirtuins viable targets for improving healthspan and lifespan? [J].

Baur, Joseph A. ;

Ungvari, Zoltan ;

Minor, Robin K. ;

Le Couteur, David G. ;

de Cabo, Rafael .

NATURE REVIEWS DRUG DISCOVERY, 2012, 11 (06) :443-461

[10] RETRACTED: Identification of a coronary vascular progenitor cell in the human heart (Retracted Article) [J].

Bearzi, Claudia ;

Leri, Annarosa ;

Lo Monaco, Francesco ;

Rota, Marcello ;

Gonzalez, Arantxa ;

Hosoda, Toru ;

Pepe, Martino ;

Qanud, Khaled ;

Ojaimi, Caroline ;

Bardelli, Silvana ;

D'Amario, Domenico ;

D'Alessandro, David A. ;

Michler, Robert E. ;

Dimmeler, Stefanie ;

Zeiher, Andreas M. ;

Urbanek, Konrad ;

Hintze, Thomas H. ;

Kajstura, Jan ;

Anversa, Piero .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (37) :15885-15890

← 1 2 3 4 5 6 7 8 9 10 →