The relation of Langerhans cell histiocytosis to acute leukemia, lymphomas, and other solid tumors -: The LCH-Malignancy Study Group of the Histiocyte Society

被引:146
作者
Egeler, RM [1 ]
Neglia, JP
Aricò, M
Favara, BE
Heitger, A
Nesbit, ME
Nicholson, HS
机构
[1] Univ Alberta, Alberta Childrens Hosp, So Alberta Childrens Canc Program, Tom Baker Canc Ctr, Calgary, AB T2T 5C7, Canada
[2] Erasmus Univ, Sophia Childrens Hosp, Div Pediat Oncol, Rotterdam, Netherlands
[3] Univ Minnesota, Sch Med, Minneapolis, MN 55455 USA
[4] Univ Pavia, Policlin San Matteo, IRCCS, Dept Pediat, I-27100 Pavia, Italy
[5] Univ Utah, Dept Pathol, Salt Lake City, UT USA
[6] NIH, Rocky Mt Labs, Hamilton, MT USA
[7] Univ Innsbruck, Childrens Hosp, Dept Pediat, A-6020 Innsbruck, Austria
[8] Oregon Hlth & Sci Univ, Dept Pediat, NRC5, Portland, OR 97201 USA
关键词
D O I
10.1016/S0889-8588(05)70516-5
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The frequency of Langerhans cell histiocytosis (LCH) and a malignant neoplasm occurring in the same individual appears to be greater than previously recognized. To define the occurrence and the pattern of these events, a Study Group of the Histiocyte Society initiated a registry of patients in whom this association occurred synchronously or asynchronously. Evaluation of 54 patients detected two patterns of associations between LCH and other disorders. First, it is possible that therapy of LCH promotes a secondary malignancy. Second, it is possible that a genetic predisposition, with or without the immunosuppression associated therapy for the malignancy, plays a role in the development and expression of disseminated LCH. Data collected by the LCH Malignancy Study Group may provide insights into the etiology and pathophysiology of LCH.
引用
收藏
页码:369 / +
页数:11
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