The N-end rule and regulation of apoptosis

被引：92

作者：

Varshavsky, A ^{[1
]}

机构：

[1] CALTECH, Div Biol, Pasadena, CA 91125 USA

来源：

NATURE CELL BIOLOGY | 2003年 / 5卷 / 05期

关键词：

D O I：

10.1038/ncb0503-373

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The ubiquitin-dependent N-end rule pathway targets proteins for degradation through their destabilizing N-terminal residues. This pathway is known to control the import of peptides, chromosome stability and cardiovascular development. A new report identifies yet another function of the N-end rule pathway: the regulation of apoptosis through degradation of Drosophila melanogaster DIAP1.

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页码：373 / 376

页数：4

相关论文

共 22 条

[1] Apoptosis-independent functions of killer caspases [J].

Algeciras-Schimnich, A ;

Barnhart, BC ;

Peter, ME .

CURRENT OPINION IN CELL BIOLOGY, 2002, 14 (06) :721-726

[2] INVIVO HALF-LIFE OF A PROTEIN IS A FUNCTION OF ITS AMINO-TERMINAL RESIDUE [J].

BACHMAIR, A ;

FINLEY, D ;

VARSHAVSKY, A .

SCIENCE, 1986, 234 (4773) :179-186

[3]

BALZI E, 1990, J BIOL CHEM, V265, P7464

[4] RGS4 is arginylated and degraded by the N-end rule pathway in vitro [J].

Davydov, IV ;

Varshavsky, A .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (30) :22931-22941

[5] Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases [J].

Deveraux, QL ;

Leo, E ;

Stennicke, HR ;

Welsh, K ;

Salvesen, GS ;

Reed, JC .

EMBO JOURNAL, 1999, 18 (19) :5242-5251

[6] Degradation of DIAP1 by the N-end rule pathway is essential for regulating apoptosis [J].

Ditzel, M ;

Wilson, R ;

Tenev, T ;

Zachariou, A ;

Paul, A ;

Deas, E ;

Meier, P .

NATURE CELL BIOLOGY, 2003, 5 (05) :467-473

[7] Pairs of dipeptides synergistically activate the binding of substrate by ubiquitin ligase through dissociation of its autoinhibitory domain [J].

Du, FY ;

Navarro-Garcia, F ;

Xia, ZX ;

Tasaki, T ;

Varshavsky, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (22) :14110-14115

[8] Cell proliferation and apoptosis [J].

Guo, M ;

Hay, BA .

CURRENT OPINION IN CELL BIOLOGY, 1999, 11 (06) :745-752

[9] Cohesin cleavage by separase required for anaphase and cytokinesis in human cells [J].

Hauf, S ;

Waizenegger, IC ;

Peters, JM .

SCIENCE, 2001, 293 (5533) :1320-1323

[10] Altered activity, social behavior, and spatial memory in mice lacking the NTAN1p amidase and the asparagine branch of the N-end rule pathway [J].

Kwon, YT ;

Balogh, SA ;

Davydov, IV ;

Kashina, AS ;

Yoon, JK ;

Xie, YM ;

Gaur, A ;

Hyde, L ;

Denenberg, VH ;

Varshavsky, A .

MOLECULAR AND CELLULAR BIOLOGY, 2000, 20 (11) :4135-4148