Native valve infective endocarditis in elderly and younger adult patients: Comparison of clinical features and outcomes with use of the Duke criteria and the Duke Endocarditis Database

被引:62
作者
Gagliardi, JP [1 ]
Nettles, RE [1 ]
McCarty, DE [1 ]
Sanders, LL [1 ]
Corey, GR [1 ]
Sexton, DJ [1 ]
机构
[1] Duke Univ, Med Ctr, Dept Med, Div Infect Dis, Durham, NC 27710 USA
关键词
D O I
10.1086/520304
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The effect of age on the presentation and outcome of infective endocarditis (IE) is unclear. Many of the available data are based on analyses of mixed populations of patients including intravenous drug users or those with prosthetic valve endocarditis or native valve IE. We used the Duke criteria to compare the characteristics of 44 episodes of definite native valve IE in elderly patients (>64 years old) with the characteristics of 64 similarly defined episodes of native valve IE in younger, nonintravenous-drug-using adult patients (>29 years and <60 years old). Our data suggest that the clinical presentation, characteristics, and outcome of native valve IE are similar for elderly patients and younger adult patients, although elderly patients were hospitalized an average of 12 days longer. Although we found that the occurrence of renal failure and cerebral embolism during an episode of IE was associated with higher rates of death (odds ratios, 4.8 and 4.0, respectively), age was not a significant contributor to mortality.
引用
收藏
页码:1165 / 1168
页数:4
相关论文
共 16 条
[1]   EVALUATION OF NEW CLINICAL-CRITERIA FOR THE DIAGNOSIS OF INFECTIVE ENDOCARDITIS [J].
BAYER, AS ;
WARD, JI ;
GINZTON, LE ;
SHAPIRO, SM .
AMERICAN JOURNAL OF MEDICINE, 1994, 96 (03) :211-219
[2]   BACTERIAL-INFECTIONS IN THE ELDERLY - SPECIAL CONSIDERATIONS FOR A SPECIAL PATIENT POPULATION [J].
BERK, SL ;
ALVAREZ, S .
POSTGRADUATE MEDICINE, 1985, 77 (03) :168-&
[3]   INFECTIVE ENDOCARDITIS IN THE AGING PATIENT [J].
CANTRELL, M ;
YOSHIKAWA, TT .
GERONTOLOGY, 1984, 30 (05) :316-326
[4]  
delPont JM, 1995, PEDIATR INFECT DIS J, V14, P1079
[5]   NEW CRITERIA FOR DIAGNOSIS OF INFECTIVE ENDOCARDITIS - UTILIZATION OF SPECIFIC ECHOCARDIOGRAPHIC FINDINGS [J].
DURACK, DT ;
LUKES, AS ;
BRIGHT, DK ;
ALBERTS, MJ ;
BASHORE, TM ;
COREY, GR ;
DOUGLAS, JM ;
GRAY, L ;
HARRELL, FE ;
HARRISON, JK ;
HEINLE, SA ;
MORRIS, A ;
KISSLO, JA ;
NICELY, LM ;
OLDHAM, N ;
PENNING, LM ;
SEXTON, DJ ;
TOWNS, M ;
WAUGH, RA .
AMERICAN JOURNAL OF MEDICINE, 1994, 96 (03) :200-209
[6]  
FINKELSTEIN MS, 1982, GERIATRICS, V37, P65
[7]   Oral antibiotic treatment of right-sided staphylococcal endocarditis in injection drug users: Prospective randomized comparison with parenteral therapy [J].
Heldman, AW ;
Hartert, TV ;
Ray, SC ;
Daoud, EG ;
Kowalski, TE ;
Pompili, VJ ;
Sisson, SD ;
Tidmore, WC ;
Eigen, KAV ;
Goodman, SN ;
Lietman, PS ;
Petty, BG ;
Flexner, C .
AMERICAN JOURNAL OF MEDICINE, 1996, 101 (01) :68-76
[8]   An evaluation of the Duke criteria in 25 pathologically confirmed cases of prosthetic valve endocarditis [J].
Nettles, RE ;
McCarty, DE ;
Corey, GR ;
Li, J ;
Sexton, DJ .
CLINICAL INFECTIOUS DISEASES, 1997, 25 (06) :1401-1403
[9]   INFECTIVE ENDOCARDITIS IN THE ELDERLY [J].
ROBBINS, N ;
DEMARIA, A ;
MILLER, MH .
SOUTHERN MEDICAL JOURNAL, 1980, 73 (10) :1335-1338
[10]  
ROBERTS R, 1990, Emergency Medicine Clinics of North America, V8, P665