The role of inflammation in depression: from evolutionary imperative to modern treatment target

被引：2861

作者：

Miller, Andrew H. ^{[1
]}

Raison, Charles L. ^{[2
]}

机构：

[1] Emory Univ, Sch Med, Winship Canc Inst, Atlanta, GA 30322 USA

[2] Univ Wisconsin, Sch Human Ecol, Madison, WI 53706 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2016年 / 16卷 / 01期

关键词：

BASE-LINE PREDICTORS; INTERFERON-ALPHA; GENETIC-VARIATION; MAJOR DEPRESSION; GLUCOCORTICOID RESISTANCE; TRANSLOCATOR PROTEIN; MOLECULAR-PATTERNS; IMMUNE STIMULATION; NLRP3; INFLAMMASOME; GLUTAMATE UPTAKE;

D O I：

10.1038/nri.2015.5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Crosstalk between inflammatory pathways and neurocircuits in the brain can lead to behavioural responses, such as avoidance and alarm, that are likely to have provided early humans with an evolutionary advantage in their interactions with pathogens and predators. However, in modern times, such interactions between inflammation and the brain appear to drive the development of depression and may contribute to non-responsiveness to current antidepressant therapies. Recent data have elucidated the mechanisms by which the innate and adaptive immune systems interact with neurotransmitters and neurocircuits to influence the risk for depression. Here, we detail our current understanding of these pathways and discuss the therapeutic potential of targeting the immune system to treat depression.

引用

页码：22 / 34

页数：13

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