Induction of drug-metabolizing enzymes: A path to the discovery of multiple cytochromes P450

被引：67

作者：

Conney, AH ^{[1
]}

机构：

[1] Rutgers State Univ, Ernest Mario Sch Pharm, Dept Biol Chem, Susan Lehman Cullman Lab Canc Res, Piscataway, NJ 08854 USA

来源：

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY | 2003年 / 43卷

关键词：

environmental regulation of xenobiotic metabolism; microsomal enzyme induction; activation of microsomal enzymes; drug-drug interactions; diet-drug interactions;

D O I：

10.1146/annurev.pharmtox.43.100901.135754

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This article provides a personal account of the discovery of the induced synthesis of drug-metabolizing enzymes and of subsequent research that led to the discovery of multiple cytochromes P450 with different catalytic activities. The manuscript also emphasizes the role of environmental factors (in addition to genetic polymorphisms) in explaining person-to-person and day-to-day differences in rates and pathways of drug metabolism that occur in the human population.

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页码：1 / 30

页数：30

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