Relationship between matrix metalloproteinase expression and tumor angiogenesis in human breast carcinoma

被引:13
作者
Kurizaki, T [1 ]
Toi, M [1 ]
Tominaga, T [1 ]
机构
[1] Tokyo Metropolitan Komagome Hosp, Dept Surg, Bunkyo Ku, Tokyo 113, Japan
关键词
matrix metalloproteinase; angiogenesis; breast neoplasm;
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Intratumoral proteases are known to be involved in not only tumor cell invasion but also a variety of stromal reactions including neovascularization. In this study, we have examined the expression of matrix metalloproteinases (MMPs) by gelatin gel zymography and compared its expression with angiogenesis activities including the expression of several endothelial growth regulators and intratumoral microvessel density (MVD) in human breast cancer tissues. There was a significant correlation between activated MMP-2 expression and vascular endothelial growth factor (VEGF) expression (p=0.045). In addition, the expression of activated MMP-9 expression was significantly correlated with thymidine phosphorylase (TP) expression (p=0.0044). Pro MMP-9 expression tended to correlated with the increment of MVD (p=0.063). MMP-2 and MMP-9 expressions were frequently co-upregulated with endothelial growth regulators in human breast cancer tissues, which underlines the cooperative function of MMPs in neovascularization.
引用
收藏
页码:673 / 677
页数:5
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