Autophagy: Can it become a potential therapeutic target? (Review)

被引：26

作者：

Bao, Xiao Hong ^{[1
]}

Naomoto, Yoshio ^{[1
]}

Hao, Hui Fang ^{[1
]}

Watanabe, Nobuyuki ^{[1
]}

Sakurama, Kazufumi ^{[1
]}

Noma, Kazuhiro ^{[1
]}

Motoki, Takayuki ^{[1
]}

Tomono, Yasuko ^{[2
]}

Fukazawa, Takuya ^{[1
]}

Shirakawa, Yasuhiro ^{[1
]}

Yamatsuji, Tomoki ^{[1
]}

Matsuoka, Junji ^{[1
]}

Takaoka, Munenori ^{[1
]}

机构：

[1] Okayama Univ, Dept Gastroenterol Surg Transplant & Surg Oncol, Grad Sch Med Dent & Pharmaceut Sci, Okayama 7008558, Japan

[2] Shigei Med Res Inst, Okayama, Japan

来源：

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE | 2010年 / 25卷 / 04期

关键词：

autophagy; protein and organelle degradation; homeostasis; protector; physiological and pathological roles human diseases; therapy; GENOME-WIDE ASSOCIATION; BREAST-CANCER CELLS; SPHINGOSINE KINASE-1; HUNTINGTONS-DISEASE; DEFICIENCY CAUSES; CROHN-DISEASE; PROTEINS; MTOR; MACROAUTOPHAGY; EXPRESSION;

D O I：

10.3892/ijmm_00000369

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Autophagy is a cellular lysosomal degradation pathway involved in proteins and organelles recycling for promoting cell survival. development and homeostasis. It is a multistep process and genetic studies have identified many proteins that participate in autophagosome formation and fusion with lysosomes, and various singaling factors that associate with the regulation of autophagy. In general, autophagy acts as a cell protector and as dysfunction is correlated with diverse pathologies. well as neurodegeneration. liver, heart and muscle diseases. cancer. inflammation and ageing. However. its role in cell death Increases the complexity of to autophagic degradation system A broad understanding of autophagy. ranging From detailed processes. including induction, formation and degradation, to function m physiology and pathology. revealed by accumulating studies. may be helpful for formulating therapeutic strategies For autophagy-associated human diseases

引用

页码：493 / 503

页数：11

共 115 条

[1] Blocked autophagy sensitizes resistant carcinoma cells to radiation therapy [J].