How reliable re-adjustment is: correspondence regarding A. Fuglsang, "The 'effective number of codons' revisited"

被引：10

作者：

Marashi, SA ^{[1
]}

Najafabadi, HS ^{[1
]}

机构：

[1] Univ Tehran, Fac Sci, Dept Biotechnol, Tehran, Iran

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2004年 / 324卷 / 01期

关键词：

effective number of codons; Nc; re-adjustment; codon usage bias;

D O I：

10.1016/j.bbrc.2004.08.213

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A. Fuglsang [Biochem. Biophys. Res. Commun. 317 (2004) 957-964] suggested that effective number of codons for individual amino acids (AY-values) should be re-adjusted to the number of synonymous codons of those amino acids, in order to prevent the overestimation of the effective number of codons. Here, it is shown that re-adjustment at the level of individual amino acids results in loss of considerable amounts of information. Furthermore, we have shown that theoretical N(c)-values arc functions of GC3s (and GC1s); as a result, when an amino acid N(c)-value exceeds the related theoretical Nc-value, the implication of re-adjustment depends on the GC composition of the gene. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：1 / 2

页数：2