Dynamic mutation: possible mechanisms and significance in human disease

被引：72

作者：

Richards, RI ^{[1
]}

Sutherland, GR ^{[1
]}

机构：

[1] UNIV ADELAIDE,DEPT GENET,ADELAIDE,SA 5000,AUSTRALIA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1997年 / 22卷 / 11期

关键词：

D O I：

10.1016/S0968-0004(97)01108-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Increases in repeat-DNA copy number are the molecular basis of a growing list of human genetic diseases, including fragile X syndrome, myotonic dystrophy, Huntington disease and a form of epilepsy. Repeat-DNA sequences undergo a unique process of dynamic mutation, the common properties of which probably reflect common molecular events. This form of mutation is no longer restricted to trinucleotide repeats, because repeats of different length have been found to undergo expansion.

引用

页码：432 / 436

页数：5

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