A review of the effects of the oral direct thrombin inhibitor ximelagatran on coagulation assays

被引:29
作者
Carlsson, SC [1 ]
Mattsson, C
Eriksson, UG
Sarich, TC
Wåhlander, K
Eliasson, Å
Karlson, BW
Sheth, SB
Held, P
机构
[1] AstraZeneca R&D, Molndal, Sweden
[2] AstraZeneca LP, Wilmington, DE USA
关键词
activated clotting time; activated partial thromboplastin time; blood coagulation tests; ecarin clotting time; oral direct thrombin inhibitors; prothrombin time; thrombin clotting time; ximelagatran;
D O I
10.1016/j.thromres.2004.07.001
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:9 / 18
页数:10
相关论文
共 60 条
[1]  
Albers GW, 2003, LANCET, V362, P1691
[2]   Pharmacokinetics, preliminary efficacy and safety of subcutaneous melagatran and oral Ximelagatran -: A multicentre study of thromboprophylaxis in elective abdominal surgery [J].
Bergqvist, D ;
Solhaug, JH ;
Holmdahl, L ;
Eriksson, UG ;
Andersson, M ;
Boberg, B ;
Ögren, M .
CLINICAL DRUG INVESTIGATION, 2004, 24 (03) :127-136
[3]   Inhibition of thrombin-induced feedback activation of factor V:: a potential pathway for inhibition of thrombin generation by melagatran [J].
Boström, SL ;
Dagnelid, E ;
Hansson, GFH ;
Ulvinge, JC .
BLOOD COAGULATION & FIBRINOLYSIS, 2004, 15 (01) :25-30
[4]   Ximelagatran, an oral direct thrombin inhibitor, has a low potential for cytochrome P450-mediated drug-drug interactions [J].
Bredberg, E ;
Andersson, TB ;
Frison, L ;
Thuresson, A ;
Johansson, S ;
Eriksson-Lepkowska, M ;
Larsson, M ;
Eriksson, UG .
CLINICAL PHARMACOKINETICS, 2003, 42 (08) :765-777
[5]   Clinical monitoring of direct thrombin inhibitors using the ecarin clotting time [J].
de Denus, S ;
Spinler, SA .
PHARMACOTHERAPY, 2002, 22 (04) :433-435
[6]   EFFECTS OF RECOMBINANT HIRUDIN (R-HIRUDIN, HBW-023) ON COAGULATION AND PLATELET ACTIVATION IN-VIVO - COMPARISON WITH UNFRACTIONATED HEPARIN AND A LOW-MOLECULAR-WEIGHT HEPARIN PREPARATION (FRAGMIN) [J].
EICHINGER, S ;
WOLZT, M ;
SCHNEIDER, B ;
NIESZPAURLOS, M ;
HEINRICHS, H ;
LECHNER, K ;
EICHLER, HG ;
KYRLE, PA .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 1995, 15 (07) :886-892
[7]   Ximelagatran and melagatran compared with dalteparin for prevention of venous thromboembolism after total hip or knee replacement:: the METHRO II randomised trial [J].
Eriksson, B ;
Bergqvist, D ;
Kälebo, P ;
Dahl, OE ;
Lindbratt, S ;
Bylock, A ;
Frison, L ;
Eriksson, UG ;
Welin, L ;
Gustafsson, D .
LANCET, 2002, 360 (9344) :1441-1447
[8]   The direct thrombin inhibitor melagatran followed by oral ximelagatran compared with enoxaparin for the prevention of venous thromboembolism after total hip or knee replacement:: the EXPRESS study [J].
Eriksson, BI ;
Agnelli, G ;
Cohen, AT ;
Dahl, OE ;
Lassen, MR ;
Mouret, P ;
Rosencher, N ;
Kälebo, P ;
Panfilov, S ;
Eskilson, C ;
Andersson, M .
JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2003, 1 (12) :2490-2496
[9]  
Eriksson BI, 2003, THROMB HAEMOSTASIS, V89, P288
[10]   Absorption, distribution, metabolism, and excretion of ximelagatran, an oral direct thrombin inhibitor, in rats, dogs, and humans [J].
Eriksson, UG ;
Bredberg, U ;
Hoffmann, KJ ;
Thuresson, A ;
Gabrielsson, M ;
Ericsson, H ;
Ahnoff, M ;
Gislén, K ;
Fager, G ;
Gustafsson, D .
DRUG METABOLISM AND DISPOSITION, 2003, 31 (03) :294-305