Physical activity and cause-specific mortality in the Whitehall study

被引:120
作者
Smith, GD
Shipley, MJ
Batty, GD
Morris, JN
Marmot, M
机构
[1] Univ Bristol, Dept Social Med, Bristol BS8 2PR, Avon, England
[2] UCL, Dept Epidemiol & Publ Hlth, London WC1E 6BT, England
[3] Univ London London Sch Hyg & Trop Med, Dept Epidemiol & Populat Hlth, London WC1E 7HT, England
[4] Univ London London Sch Hyg & Trop Med, Hlth Promot Res Unit, London WC1E 7HT, England
基金
英国医学研究理事会;
关键词
physical activity; exercise; cancer; coronary heart disease; stroke; mortality;
D O I
10.1016/S0033-3506(00)00353-X
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
A prospective cohort study of London civil servants was used to examine the relation of physical activity to various causes of death. 6.702 men aged 40-64y who participated in a baseline examination between 1969 and 1970 were followed up for 25y during which time there were 2859 deaths. The association of two measures of physical activity (leisure time activity and usual walking pace) with cause-specific mortality was examined. Walking pace demonstrated inverse relations with mortality from all-causes, coronary heart disease (CHD), other cardiovascular disease (CVD), all cancers, respiratory disease, colorectal cancer and haematopoietic cancer following adjustment fur risk factors which included age, employment grade, smoking, body mass index, and forced expiratory volume (P [trend] < 0.05 for all). In analyses restricted to men without disease at entry, walking pace retained inverse associations with all-cause, CHD. other cardiovascular disease. and haematopoietic cancer mortality (P [trend] < 0.05 for all). Leisure time activity was also inversely associated with mortality from all-causes, CHD, other CVD, and all-cancers following adjustment for risk factors (P [trend] < 0.05 for all). Eliminating deaths in the first 5 and 10y of follow-up did not greatly alter these associations. It is concluded that physical activity may confer protection against death due to some cancers, in addition to reducing cardiovascular disease risk.
引用
收藏
页码:308 / 315
页数:8
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