Regulation of ceramide production and apoptosis

被引：708

作者：

Kolesnick, RN

Krönke, M

机构：

[1] Mem Sloan Kettering Canc Ctr, Lab Signal Transduct, New York, NY 10021 USA

[2] Univ Kiel, Med Ctr, Inst Immunol, D-24105 Kiel, Germany

来源：

ANNUAL REVIEW OF PHYSIOLOGY | 1998年 / 60卷

关键词：

sphingomyelinase; caspases; sphingosine; mitochondria; Bcl-2;

D O I：

10.1146/annurev.physiol.60.1.643

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Ceramide is a sphingosine-based lipid signaling molecule that regulates cellular differentiation, proliferation, and apoptosis. The emerging picture suggests that coupling of ceramide to specific signaling cascades is both stimulus and cell-type specific. Ceramide action is determined within the context of other stimuli and by the subcellular topology of its production. Here, we discuss the pathways of ceramide generation and the interaction of ceramide with caspases and other apoptotic signaling cascades.

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收藏

页码：643 / 665

页数：23

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