Metabolomics: beyond biomarkers and towards mechanisms

被引：2519

作者：

Johnson, Caroline H. ^{[1
]}

Ivanisevic, Julijana ^{[2
]}

Siuzdak, Gary ^{[3
,4
]}

机构：

[1] Yale Univ, Sch Publ Hlth, Dept Environm Hlth Sci, 60 Coll St, New Haven, CT 06520 USA

[2] Univ Lausanne, Fac Biol & Med, Metabol Res Platform, Rue Bugnon 19, CH-1005 Lausanne, Switzerland

[3] Scripps Res Inst, Scripps Ctr Metabol & Mass Spectrometry, Dept Chem, 10550 North Torrey Pines Rd, La Jolla, CA 92037 USA

[4] Scripps Res Inst, Scripps Ctr Metabol & Mass Spectrometry, Dept Mol & Computat Biol, 10550 North Torrey Pines Rd, La Jolla, CA 92037 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2016年 / 17卷 / 07期

基金：

美国国家卫生研究院;

关键词：

CELL LUNG-CANCER; URINARY BIOMARKERS; NONHUMAN-PRIMATES; GUT MICROBIOTA; WEB SERVER; METABOLISM; IDENTIFICATION; PHOSPHATIDYLCHOLINE; IMMUNOTHERAPY; INHIBITION;

D O I：

10.1038/nrm.2016.25

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Metabolomics, which is the profiling of metabolites in biofluids, cells and tissues, is routinely applied as a tool for biomarker discovery. Owing to innovative developments in informatics and analytical technologies, and the integration of orthogonal biological approaches, it is now possible to expand metabolomic analyses to understand the systems-level effects of metabolites. Moreover, because of the inherent sensitivity of metabolomics, subtle alterations in biological pathways can be detected to provide insight into the mechanisms that underlie various physiological conditions and aberrant processes, including diseases.

引用

页码：451 / 459

页数：9

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