Evaluation of STOX1 as a preeclampsia candidate gene in a population-wide sample

被引：34

作者：

Kivinen, Katja

Peterson, Hanna

Hiltunen, Leena

Laivuori, Hannele

Heino, Sanna

Tiala, Inkeri

Knuutila, Sakari

Rasi, Vesa

Kere, Juha ^{[1
]}

机构：

[1] Karolinska Inst, Novum, Dept Biosci, S-14157 Huddinge, Sweden

[2] Univ Helsinki, Dept Med Genet, Helsinki, Finland

[3] Univ Helsinki, Cent Hosp, Dept Clin Genet, Helsinki, Finland

[4] Univ Helsinki, Dept Pathol, Lab Cytomol Genet, Helsinki, Finland

[5] Finnish Red Cross Blood Serv, Helsinki, Finland

来源：

EUROPEAN JOURNAL OF HUMAN GENETICS | 2007年 / 15卷 / 04期

关键词：

genetic association; gene expression; genetic linkage; pregnancy; complication;

D O I：

10.1038/sj.ejhg.5201788

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Preeclampsia is a common, pregnancy-specific vascular disorder characterised by hypertension and proteinuria. A recent report suggested association of the STOX1 gene on chromosome 10q22.1 with preeclampsia in the Dutch population. Here, we present a comprehensive assessment of STOX1 as a candidate gene for preeclampsia in the Finnish population by re-examining our previous genetic linkage analysis results for both chromosome 10 and paralogous loci, by genotyping representative markers in a nationwide data set, and by studying STOX1 expression in placentas from preeclamptic and uncomplicated pregnancies. In conclusion, we are unable to validate STOX1 as a common preeclampsia susceptibility gene.

引用

页码：494 / 497

页数：4

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