Nephropathic complication of type-2 diabetes is following pattern of autoimmune diseases?

被引：59

作者：

Arababadi, Mohammad Kazemi ^{[1
]}

Nosratabadi, Reza ^{[2
]}

Hassanshahi, Gholamhossein ^{[1
]}

Yahini, Narges ^{[3
]}

Pooladvand, Vahid ^{[3
]}

Shamsizadeh, Ali ^{[4
]}

Hakimi, Hamid ^{[1
]}

Derakhshan, Reza ^{[5
]}

机构：

[1] Rafsanjan Univ Med Sci, Fac Med, Dept Microbiol Hematol & Immunol, Rafsanjan, Iran

[2] Islamic Azad Univ, Fac Med, Dept Lab Sci, Zahedan Branch, Zahedan, Iran

[3] Rafsanjan Univ Med Sci, Fac Med, Dept Biochem, Rafsanjan, Iran

[4] Rafsanjan Univ Med Sci, Fac Med, Dept Physiol, Rafsanjan, Iran

[5] Rafsanjan Univ Med Sci, Ali Ebne Abitaleb Hosp, Rafsanjan, Iran

来源：

DIABETES RESEARCH AND CLINICAL PRACTICE | 2010年 / 87卷 / 01期

关键词：

IFN-gamma; IL-17A; Diabetes; Nephropathy; NECROSIS-FACTOR-ALPHA; INTERFERON-GAMMA; TNF-ALPHA; T-CELLS; SERUM; CYTOKINES; INTERLEUKIN-17; INDUCTION; MELLITUS; PROFILE;

D O I：

10.1016/j.diabres.2009.09.027

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The impact of several environmental and genetic factors on diabetes and its complications is well documented. The present study was aimed to examine the serum levels of IL-17A and IFN-gamma as antagonistic cytokines in nephropathic and non-nephropathic type-2 diabetic patients. in this experimental study, serum samples were obtained from 180 type-2 diabetic patients, 100 nephropathic type-2 diabetic patients and 100 healthy controls. Serum levels of IL-17A and IFN-gamma was detected by ELISA. Results of this study showed that the serum level of IFN-gamma was higher in both diabetic patients (nephropathic and non-nephropathic) in comparison to the controls. In terms of IL-17A, while non-nephropathic type-2 diabetic patients showed an increased serum level of it, the other patients group had a lower serum level. Based on these findings, it can be concluded that the lower serum level of IL-17A is possibly associated with nephropathic complications of type-2 diabetes. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

引用

页码：33 / 37

页数：5

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