The first synthesis of 4-trifluoromethyl-2H-pyrans by palladium-catalyzed cyclization of (E)-3-alkynyl-3-trifluoromethyl allylic alcohols

被引：40

作者：

Qing, FL ^{[1
]}

Gao, WZ ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, Lab Organofluorine Chem, Shanghai 200032, Peoples R China

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 40期

基金：

中国国家自然科学基金;

关键词：

D O I：

10.1016/S0040-4039(00)01333-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The cross-coupling of (Z)-3-iodo-3-trifluoromethyl allylic alcohols 4 with terminal alkynes 5 in the presence of Pd(PPh3)(4) and CuI gave conjugated (E)-3-alkynyl-3-trifluoromethyl allylic alcohols 2 in high yield. 4-Trifluoromethyl-2N-pyrans 7 were prepared from the cyclization of 2 using PdCl2(CH3CN)(2) catalysis. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：7727 / 7730

页数：4

共 18 条

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