A fast and inexpensive method for N-terminal fluorescein-labeling of peptides

被引：82

作者：

Weber, PJA ^{[1
]}

Bader, JE ^{[1
]}

Folkers, G ^{[1
]}

Beck-Sickinger, AG ^{[1
]}

机构：

[1] Swiss Fed Inst Technol, Dept Pharm, CH-8057 Zurich, Switzerland

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 06期

关键词：

D O I：

10.1016/S0960-894X(98)00084-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new method has been developed to synthesize fluorescein labeled peptides, compounds of increasing importance in bioorganic chemistry, cell biology, pharmacology, drug targeting and medicinal chemistry. We show, that 4(5)-carboxyfluorescein is much more efficient than the hitherto predominantly utilized reagents 4 (5)-carboxyfluorescein-N-succinimidylester and 4(5)-fluoresceinisothiocyanate. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：597 / 600

页数：4

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