Structural elucidation and antitumor activity of a fructan from Cyathula officinalis Kuan

被引：54

作者：

Chen, XM ^{[1
]}

Tian, GY ^{[1
]}

机构：

[1] Acad Sinica, Shanghai Inst Organ Chem, State Key Lab Bioorgan & Nat Prod Chem, Shanghai 200032, Peoples R China

来源：

CARBOHYDRATE RESEARCH | 2003年 / 338卷 / 11期

关键词：

fructan; reductive-cleavage; Cyathula officinalis Kuan; antitumor;

D O I：

10.1016/S0008-6215(03)00073-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A fructan named CoPS3 was isolated from Cyathula officinalis Kuan. The structure of CoPS3 was determined by methylation, by the reductive-cleavage method combined with GC-MS analysis, and both 1D and 2D H-1 and C-13 NMR spectroscopy. These results show that CoPS3 is a graminans-type fructan that is comprised of a beta-D-fructofuranosyl backbone having residues linked (2-->1)- and (2-->6) with branches and an alpha-D-ghlcopyranose residue on the nonreducing end of the fructan chain. Each branch is terminated by a beta-D-Fruf residue. Bioassay showed that it could inhibit growth of Lewis pulmonary carcinoma implanted in mice. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：1235 / 1241

页数：7

共 18 条

[1] DETERMINATION OF THE STRUCTURES OF TRISACCHARIDES BY C-13-NMR SPECTROSCOPY [J].