Stimulation by proopiomelanocortin-derived peptides of LH release by bullfrog dispersed anterior pituitary cells

被引：6

作者：

Aida, T ^{[1
]}

Oguchi, A ^{[1
]}

Iwamuro, S ^{[1
]}

Yamamoto, K ^{[1
]}

Kikuyama, S ^{[1
]}

机构：

[1] Waseda Univ, Sch Educ, Dept Biol, Tokyo 16950, Japan

来源：

ZOOLOGICAL SCIENCE | 1997年 / 14卷 / 05期

关键词：

D O I：

10.2108/zsj.14.827

中图分类号：

Q95 [动物学];

学科分类号：

071002 ;

摘要：

Labeling and immunoprecipitation experiments confirmed that three proopiomelanocortin (POMC)-derived peptides, the N-terminal peptide of POMC (NPP), joining peptide (JP) and adrenocorticotropic hormone (ACTH), were released by the bullfrog (Rana catesbeiana) anterior pituitary. The effects of these three peptides on luteinizing hormone (LH) release by bullfrog dispersed anterior pituitary cells were studied. NPP and ACTH, but not JP, enhanced LH release concentration-dependently. Approximately 6 hr elapsed before the gonadotrophs responded to NPP and ACTH by releasing LH, whereas their response to human GnRH (hGnRH) was faster, suggesting that the modes of action of these two peptides and hGnRH differ. These results raise the possibility that NPP and ACTH act as paracrine factors in the bullfrog pituitary to enhance LH release either directly or indirectly.

引用

页码：827 / 831

页数：5

共 34 条

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