Commentary: New insights into the subversion of the chemokine system by poxviruses

被引：17

作者：

Alcami, Antonio ^{[1
]}

机构：

[1] UAM, CSIC, Ctr Bio Mol Severo Ochoa, Madrid, Spain

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 2007年 / 37卷 / 04期

基金：

英国医学研究理事会;

关键词：

chemokines; dendritic cell; immune evasion; vaccinia virus;

D O I：

10.1002/eji.200737215

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Viruses encode immune evasion mechanisms to survive in the immunocompetent host. Chemokines mediate the migration of immune cells and their critical role in immunity is emphasized by the numerous virus-encoded strategies to modulate their activity. Evidence published in this issue of the European Journal of Immunology uncovers novel mechanisms encoded by vaccinia virus to inhibit the chemokine-mediated migration of DC, an important event in the initiation of the immune response to viral infections.

引用

页码：880 / 883

页数：4

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