Parkinson's Disease Dementia

被引：16

作者：

Docherty, Mary J. ^{[2
]}

Burn, David J. ^{[1
,2
]}

机构：

[1] Newcastle Univ, Clin Ageing Res Unit, Newcastle Upon Tyne NE4 5PL, Tyne & Wear, England

[2] Newcastle Univ, Inst Ageing & Hlth, Newcastle Upon Tyne NE4 5PL, Tyne & Wear, England

来源：

CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS | 2010年 / 10卷 / 04期

关键词：

Parkinson's disease; Dementia; Epidemiology; Pathology; Diagnosis; Treatment; COGNITIVE IMPAIRMENT; COMMUNITY POPULATION; DIAGNOSTIC-CRITERIA; SYDNEY MULTICENTER; RATING-SCALE; BRAIN; PATHOLOGY; HETEROGENEITY; MEMANTINE; SYMPTOMS;

D O I：

10.1007/s11910-010-0113-7

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

Dementia associated with Parkinson's disease (PDD) is a common problem and one that is associated with significant morbidity and mortality. Over the past decade, increasing research efforts and funding have been directed toward an improved understanding of PDD. Despite these efforts, fundamental gaps remain in our knowledge. Consequently, therapeutic progress has been frustratingly slow and incomplete. To significantly affect PDD, novel "disease-modifying" agents, rather than more traditional neurotransmitter replacement approaches, likely will be required.

引用

页码：292 / 298

页数：7

共 42 条

[1]

Cognitive impairment in incident, untreated Parkinson disease The Norwegian ParkWest Study [J].

Aarsland, D. ;

Bronnick, K. ;

Larsen, J. P. ;

Tysnes, O. B. ;

Alves, G. .

NEUROLOGY, 2009, 72 (13) :1121-1126

[2]

The epidemiology of dementia associated with Parkinson disease [J].

Aarsland, Dag ;

Kurz, Martin Wilhelm .

JOURNAL OF THE NEUROLOGICAL SCIENCES, 2010, 289 (1-2) :18-22

[3]

Memantine in patients with Parkinson's disease dementia or dementia with Lewy bodies: a double-blind, placebo-controlled, multicentre trial [J].

Aarsland, Dag ;

Ballard, Clive ;

Walker, Zuzana ;

Bostrom, Fredrik ;

Alves, Guido ;

Kossakowski, Katja ;

Leroi, Iracema ;

Pozo-Rodriguez, Francisco ;

Minthon, Lennart ;

Londos, Elisabet .

LANCET NEUROLOGY, 2009, 8 (07) :613-618

[4]

Cognitive assessment of a representative community population with Parkinson's disease (PD) using the Cambridge Cognitive Assessment-Revised (CAMCOG-R) [J].

Athey, RJ ;

Porter, RW ;

Walker, RW .

AGE AND AGEING, 2005, 34 (03) :268-273

[5]

Staging of brain pathology related to sporadic Parkinson's disease [J].

Braak, H ;

Del Tredici, K ;

Rüb, U ;

de Vos, RAI ;

Steur, ENHJ ;

Braak, E .

NEUROBIOLOGY OF AGING, 2003, 24 (02) :197-211

[6]

Motor subtype and cognitive decline in Parkinson's disease, Parkinson's disease with dementia, and dementia with Lewy bodies [J].

Burn, DJ ;

Rowan, EN ;

Allan, LM ;

Molloy, S ;

T O'Brien, J ;

McKeith, IG .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2006, 77 (05) :585-589

[7]

Dementia and survival in Parkinson disease - A 12-year population study [J].

Buter, T. C. ;

van den Hout, A. ;

Matthews, F. E. ;

Larsen, J. P. ;

Brayne, C. ;

Aarsland, D. .

NEUROLOGY, 2008, 70 (13) :1017-1022

[8]

Donepezil markedly potentiates memantine neurotoxicity in the adult rat brain [J].

Creeley, Catherine E. ;

Wozniak, David F. ;

Nardi, Anthony ;

Farber, Nuri B. ;

Olney, John W. .

NEUROBIOLOGY OF AGING, 2008, 29 (02) :153-167

[9]

Dickson DW, 2009, LANCET NEUROL, V8, P1150, DOI 10.1016/S1474-4422(09)70238-8

[10]

Projected number of people with Parkinson disease in the most populous nations, 2005 through 2030 [J].

Dorsey, E. R. ;

Constantinescu, R. ;

Thompson, J. P. ;

Biglan, K. M. ;

Holloway, R. G. ;

Kieburtz, K. ;

Marshall, F. J. ;

Ravina, B. M. ;

Schifitto, G. ;

Siderowf, A. ;

Tanner, C. M. .

NEUROLOGY, 2007, 68 (05) :384-386

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