Oligomeric Alpha-synuclein and Its Role in Neuronal Death

被引：61

作者：

Brown, David R. ^{[1
]}

机构：

[1] Univ Bath, Dept Biol & Biochem, Bath BA2 7AY, Avon, England

来源：

IUBMB LIFE | 2010年 / 62卷 / 05期

关键词：

Parkinson's disease; toxicity; Lewy bodies; metal; copper; MULTIPLE SYSTEM ATROPHY; N-TERMINAL FRAGMENTS; PARKINSONS-DISEASE; COPPER(II) BINDING; CEREBROSPINAL-FLUID; METAL-BINDING; LEWY BODIES; BETA-SHEET; FIBRILLATION; DEMENTIA;

D O I：

10.1002/iub.316

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Alpha-synuclein is a natively unfolded protein associated with a number of neurodegenerative disorders that include Parkinson's disease. In the past, research has focused on the fibrillar form of the protein. Current research now indicates that oligomeric alpha-synuclein is the form of the protein most likely to causes neuronal death. Recent research has suggested that a unique oligomer associated with the copper binding capacity of the protein is the neurotoxic form of the protein. This review looks at the evidence for this possibility. (C) 2010 IUBMB IUBMB Life, 62(5): 334-339, 2010

引用

页码：334 / 339

页数：6

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