Iron-Catalyzed Direct Arylation of Unactivated Arenes with Aryl Halides

被引：152

作者：

Liu, Wei ^{[1
]}

Cao, Hao ^{[1
]}

Lei, Aiwen ^{[1
,2
]}

机构：

[1] Wuhan Univ, Coll Chem & Mol Sci, Wuhan 430072, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 11期

基金：

中国国家自然科学基金;

关键词：

aryl halides; biaryls; C-H activation; cross-coupling; iron; C-H BOND; CROSS-COUPLING REACTION; DIRECT FUNCTIONALIZATION; GRIGNARD-REAGENTS; ACTIVATION; EFFICIENT; IODIDES; CHLORIDES; INDOLES; ALKENYLATION;

D O I：

10.1002/anie.200906870

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Iron tough: Various aryl halides were treated with unactivated arenes to form biaryl compounds in moderate to good yields. The reactions were carried out at relatively low temperature in the presence of a catalytic amount of FeCl3, with DMEDA as the ligand and LiHMDS as the base (see scheme; DMEDA=N,N'-dimethylethane-1,2-diamine, HDMS=hexamethyldisilazanide) . © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：2004 / 2008

页数：5

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