Genome-wide analysis of acute myeloid leukemia with normal karyotype reveals a unique pattern of homeobox gene expression distinct from those with translocation-mediated fusion events
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Debernardi, S
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机构:Univ London, Barts & Royal London Sch Med & Dent, Med Oncol Unit, Canc Res UK, London EC1M 6BQ, England
Debernardi, S
Lillington, DM
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机构:Univ London, Barts & Royal London Sch Med & Dent, Med Oncol Unit, Canc Res UK, London EC1M 6BQ, England
Lillington, DM
Chaplin, T
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机构:Univ London, Barts & Royal London Sch Med & Dent, Med Oncol Unit, Canc Res UK, London EC1M 6BQ, England
Chaplin, T
Tomlinson, S
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机构:Univ London, Barts & Royal London Sch Med & Dent, Med Oncol Unit, Canc Res UK, London EC1M 6BQ, England
Tomlinson, S
Amess, J
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机构:Univ London, Barts & Royal London Sch Med & Dent, Med Oncol Unit, Canc Res UK, London EC1M 6BQ, England
Amess, J
Rohatiner, A
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机构:Univ London, Barts & Royal London Sch Med & Dent, Med Oncol Unit, Canc Res UK, London EC1M 6BQ, England
Rohatiner, A
Lister, TA
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机构:Univ London, Barts & Royal London Sch Med & Dent, Med Oncol Unit, Canc Res UK, London EC1M 6BQ, England
Lister, TA
Young, BD
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机构:Univ London, Barts & Royal London Sch Med & Dent, Med Oncol Unit, Canc Res UK, London EC1M 6BQ, England
Young, BD
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[1] Univ London, Barts & Royal London Sch Med & Dent, Med Oncol Unit, Canc Res UK, London EC1M 6BQ, England
[2] Computat Genome Anal Lab, Canc Res UK, London, England
[3] St Bartholomews Hosp, Dept Haematol, London, England
Gene expression profiles were determined from presentation peripheral blood and bone marrow samples of 28 patients with acute myeloid leukemia (AML). Hierarchical clustering sorted the profiles into separate groups, each representing one of the major cytogenetic classes in AML [i.e., t(8;21), t(15; 17), inv(16), 11q23, and normal karyotype]. Statistical group comparison identified genes whose expression was strongly correlated with these chromosomal classes. Moreover, the normal karyotype AMLs were characterized by distinctive up-regulation of certain members of the class I homeobox A and B gene families, implying a common underlying genetic lesion. These data reveal novel diagnostic and therapeutic targets and demonstrate the potential of microarray-based dissection of AML. (C) 2003 Wiley-Liss, Inc.