Actin-related proteins in the nucleus: life beyond chromatin remodelers

被引：54

作者：

Dion, Vincent ^{[1
]}

Shimada, Kenji ^{[1
]}

Gasser, Susan M. ^{[1
]}

机构：

[1] Friedrich Miescher Inst Biomed Res, CH-4058 Basel, Switzerland

来源：

CURRENT OPINION IN CELL BIOLOGY | 2010年 / 22卷 / 03期

关键词：

SACCHAROMYCES-CEREVISIAE; GENE LOOPS; ARP2/3; COMPLEX; HISTONE H2AZ; HSA DOMAIN; INO80; YEAST; TRANSCRIPTION; SWR1; REPLICATION;

D O I：

10.1016/j.ceb.2010.02.006

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Since their discovery in the mid-1990s, nuclear actin-related proteins (ARPs) have gained attention for their roles as structural components of ATP-dependent chromatin-remodeling complexes. These remodelers can move nucleosomes along the DNA, evict them from chromatin, and exchange histone variants to alter chromatin states locally. Chromatin-remodeling facilitates DNA-templated processes such as transcription regulation, DNA replication, and repair. Consistent with a role for ARPs in shaping chromatin structure, recent genetic studies show that they affect developmental and cell-type specific transcriptional programming. Here, we focus on recent results that suggest a specific contribution of ARPs to long-range interactions in the nucleus, and review evidence indicating that some ARPs may act independently of chromatin-remodeling machines.

引用

收藏

页码：383 / 391

页数：9

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