Dual catalyst control in the chiral diamine-dipeptide-catalyzed asymmetric Michael addition

被引：70

作者：

Tsogoeva, SB ^{[1
]}

Jagtap, SB ^{[1
]}

机构：

[1] Univ Gottingen, Inst Organ & Biomol Chem, D-37077 Gottingen, Germany

来源：

SYNLETT | 2004年 / 14期

关键词：

asymmetric organocatalysis; peptides; Michael additions; amines;

D O I：

10.1055/s-2004-834830

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

By example of conjugate addition of 2-nitropropane to 2-cyclohexen-1-one, it is shown that the combination of H-Leu-His-OH and (1R,2R)-(+)-1,2-diphenylethylenediamine as co-catalysts in a suitable ratio can lead to a new catalytic system for the C-C bond formation reactions. Although neither co-catalyst is Sufficiently effective independently in terms of yield or enantioselectivity, their combination results in a drastic increase in yields (up to 86%) and absolute selectivities (up to 91% ee).

引用

页码：2624 / 2626

页数：3

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