Nuclease-resistant synthetic ribozymes: developing a new class of therapeutics

被引:105
作者
Usman, N [1 ]
Blatt, LRM [1 ]
机构
[1] Ribozyme Pharmaceut Inc, Res & Dev, Boulder, CO 80301 USA
关键词
D O I
10.1172/JCI11631
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
[No abstract available]
引用
收藏
页码:1197 / 1202
页数:6
相关论文
共 25 条
[1]   CHEMICAL MODIFICATION OF HAMMERHEAD RIBOZYMES - CATALYTIC ACTIVITY AND NUCLEASE RESISTANCE [J].
BEIGELMAN, L ;
MCSWIGGEN, JA ;
DRAPER, KG ;
GONZALEZ, C ;
JENSEN, K ;
KARPEISKY, AM ;
MODAK, AS ;
MATULICADAMIC, J ;
DIRENZO, AB ;
HAEBERLI, P ;
SWEEDLER, D ;
TRACZ, D ;
GRIMM, S ;
WINCOTT, FE ;
THACKRAY, VG ;
USMAN, N .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (43) :25702-25708
[2]   SEQUENCE-ANALYSIS OF THE 5' NONCODING REGION OF HEPATITIS-C VIRUS [J].
BUKH, J ;
PURCELL, RH ;
MILLER, RH .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (11) :4942-4946
[3]   INVITRO SPLICING OF THE RIBOSOMAL-RNA PRECURSOR OF TETRAHYMENA - INVOLVEMENT OF A GUANOSINE NUCLEOTIDE IN THE EXCISION OF THE INTERVENING SEQUENCE [J].
CECH, TR ;
ZAUG, AJ ;
GRABOWSKI, PJ .
CELL, 1981, 27 (03) :487-496
[4]   ISOLATION OF A CDNA CLONE DERIVED FROM A BLOOD-BORNE NON-A, NON-B VIRAL-HEPATITIS GENOME [J].
CHOO, QL ;
KUO, G ;
WEINER, AJ ;
OVERBY, LR ;
BRADLEY, DW ;
HOUGHTON, M .
SCIENCE, 1989, 244 (4902) :359-362
[5]   THE REGULATION OF BLOOD-VESSEL GROWTH BY VASCULAR ENDOTHELIAL GROWTH-FACTOR [J].
FERRARA, N ;
HEINSOHN, H ;
WALDER, CE ;
BUNTING, S ;
THOMAS, GR .
CARDIAC GROWTH AND REGENERATION, 1995, 752 :246-256
[6]  
FOLKMAN J, 1971, NEW ENGL J MED, V285, P1182
[7]   THE RNA MOIETY OF RIBONUCLEASE-P IS THE CATALYTIC SUBUNIT OF THE ENZYME [J].
GUERRIERTAKADA, C ;
GARDINER, K ;
MARSH, T ;
PACE, N ;
ALTMAN, S .
CELL, 1983, 35 (03) :849-857
[8]  
Henry SP, 1997, ANTI-CANCER DRUG DES, V12, P395
[9]   Hepatitis C: The clinical spectrum of disease [J].
Hoofnagle, JH .
HEPATOLOGY, 1997, 26 (03) :S15-S20
[10]   Poliovirus chimeras replicating under the translational control of genetic elements of hepatitis C virus reveal unusual properties of the internal ribosomal entry site of hepatitis C virus [J].
Lu, HH ;
Wimmer, E .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (04) :1412-1417