Intrauterine programming of cardiovascular disease by maternal nutritional status

被引：76

作者：

Langley-Evans, SC ^{[1
]}

Gardner, DS ^{[1
]}

Welham, SJM ^{[1
]}

机构：

[1] Univ Southampton, Inst Human Nutr, Southampton SO16 7PX, Hants, England

来源：

NUTRITION | 1998年 / 14卷 / 01期

基金：

英国惠康基金;

关键词：

hypertension; programming; maternal nutrition;

D O I：

10.1016/S0899-9007(97)00391-2

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

The origins of cardiovascular disease are related to genetic factors, postnatal environmental and behavioral influences, and also the environment experienced in utero. Patterns of disproportionate fetal growth consistent with maternal undernutrition appear to be predictive of later hypertension and coronary heart disease. These findings from epidemiologic studies are strongly supported by animal studies. Experimental models are suggestive of a role for glucocorticoid hormones in the intrauterine programming of cardiovascular function. New understanding of the relationships between maternal diet and the development and maturation of fetal tissues may enable prevention of cardiovascular disease by intervention in early life. (C) Elsevier Science Inc. 1998.

引用

页码：39 / 47

页数：9

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