Manipulation of the bacterial flora in inflammatory bowel disease

被引：37

作者：

Marteau, P

Seksik, P

Shanahan, F

机构：

[1] Hop Europeen Georges Pompidou, Dept Gastroenterol, AP HP, F-75908 Paris 15, France

[2] Univ Paris 05, F-75270 Paris 06, France

[3] Natl Univ Ireland Univ Coll Cork, Cork, Ireland

来源：

BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY | 2003年 / 17卷 / 01期

关键词：

bacterial flora; inflammatory bowel disease; probiotics; antibiotics; Crohn's disease; ulcerative colitis; pouchitis;

D O I：

10.1053/bega.2002.0344

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

In this chapter we summarize the clinical and experimental data which indicate that bacteria, especially from the endogenous microflora, play a role in the pathogenesis of Crohn's disease, ulcerative colitis and pouchitis. We review the clinical trials, focusing on randomized controlled trials which used antibiotics or probiotics to treat situations of IBD or prevent recurrence, and we discuss the future of this approach.

引用

页码：47 / 61

页数：15

共 93 条

[1] CONTROLLED TRIAL OF ANTIMYCOBACTERIAL THERAPY IN CROHNS-DISEASE - CLOFAZIMINE VERSUS PLACEBO [J].