Rubiasins A-C, new anthracene derivatives from the roots and stems of Rubia cordifolia

被引：33

作者：

Chang, LC

Chávez, D

Gills, JJ

Fong, HHS

Pezzuto, JM

Kinghorn, AD ^{[1
]}

机构：

[1] Univ Illinois, Coll Pharm, Program Collaborat Res Pharmaceut Sci, Chicago, IL 60612 USA

[2] Univ Illinois, Coll Pharm, Dept Med Chem & Pharmacognosy, Chicago, IL 60612 USA

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 37期

关键词：

D O I：

10.1016/S0040-4039(00)01205-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Three new anthracene derivatives. rubiasins A-C (1-3), were isolated from the combined roots and stems of Rubin cordifolia, and their structures were elucidated by spectroscopic analysis. Their absolute configurations were determined by Mosher ester methodology. A known compound, mollugin (4), was obtained as an active antiproliferative principle by bioassay-monitored fractionation using a human colon cancer (Col2) cell line. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：7157 / 7162

页数：6

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