VanE-type vancomycin-resistant Enterococcus faecalis clinical isolates from Australia

被引：11

作者：

Abadía-Patiño, L

Christiansen, K

Bell, J

Courvalin, P

Périchon, B

机构：

[1] Inst Pasteur, Unite Agents Antibacteriens, F-75724 Paris 15, France

[2] Royal Perth Hosp, Dept Microbiol & Infect Dis, Perth, WA, Australia

[3] Womens & Childrens Hosp, Adelaide, SA, Australia

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2004年 / 48卷 / 12期

关键词：

D O I：

10.1128/AAC.48.12.4882-4885.2004

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Three distinct Enterococcus faecalis VanE-type isolates-BM4574, BM4575, and BM4576-obtained in Australia were studied. Expression of the resistance genes was constitutive in BM4575, probably due to a 2-bp deletion into the vanS(E) gene, and inducible in BM4574 and BM4576. Transcription analysis of the vanE operons suggested that the five genes were cotranscribed from an initiation site located 25 bp upstream from the ATG start codon of vanE.

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页码：4882 / 4885

页数：4

相关论文

共 24 条

[1] The VanS sensor negatively controls VanR-mediated transcriptional activation of glycopeptide resistance genes of Tn1546 and related elements in the absence of induction [J].

Arthur, M ;

Depardieu, F ;

Gerbaud, G ;

Galimand, M ;

Leclercq, R ;

Courvalin, P .

JOURNAL OF BACTERIOLOGY, 1997, 179 (01) :97-106

[2] Quantitative analysis of the metabolism of soluble cytoplasmic peptidoglycan precursors of glycopeptide-resistant enterococci [J].

Arthur, M ;

Depardieu, F ;

Reynolds, P ;

Courvalin, P .

MOLECULAR MICROBIOLOGY, 1996, 21 (01) :33-44

[3] Mechanisms of glycopeptide resistance in enterococci [J].

Arthur, M ;

Reynolds, PE ;

Depardieu, F ;

Evers, S ;

DutkaMalen, S ;

Quintiliani, R ;

Courvalin, P .

JOURNAL OF INFECTION, 1996, 32 (01) :11-16

[4] Glycopeptide resistance in enterococci [J].

Arthur, M ;

Reynolds, P ;

Courvalin, P .

TRENDS IN MICROBIOLOGY, 1996, 4 (10) :401-407

[5] Mutations leading to increased levels of resistance to glycopeptide antibiotics in VanB-type enterococci [J].

Baptista, M ;

Depardieu, F ;

Reynolds, P ;

Courvalin, P ;

Arthur, M .

MOLECULAR MICROBIOLOGY, 1997, 25 (01) :93-105

[6] Molecular characterization of the vanE gene cluster in vancomycin-resistant Enterococcus faecalis N00-410 isolated in Canada [J].

Boyd, DA ;

Cabral, T ;

Van Caeseele, P ;

Wylie, J ;

Mulvey, MR .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2002, 46 (06) :1977-1979

[7] Eradication of a large outbreak of a single strain of vanB vancomycin-resistant Enterococcus faecium at a major Australian teaching hospital [J].

Christiansen, KJ ;

Tibbett, PA ;

Beresford, W ;

Pearman, JW ;

Lee, RC ;

Coombs, GW ;

Kay, ID ;

O'Brien, FG ;

Palladino, S ;

Douglas, CR ;

Montgomery, PD ;

Orrell, T ;

Peterson, AM ;

Kosaras, FR ;

Flexman, JP ;

Heath, CH ;

McCullough, CA .

INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY, 2004, 25 (05) :384-390

[8] A six amino acid deletion, partially overlapping the VanSB G2 ATP-binding motif, leads to constitutive glycopeptide resistance in VanB-type Enterococcus faecium [J].

Depardieu, F ;

Courvalin, P ;

Msadek, T .

MOLECULAR MICROBIOLOGY, 2003, 50 (03) :1069-1083

[9] The vanG glycopeptide resistance operon from Enterococcus faecalis revisited [J].

Depardieu, F ;

Bonora, MG ;

Reynolds, PE ;

Courvalin, P .

MOLECULAR MICROBIOLOGY, 2003, 50 (03) :931-948

[10] VanE, a new type of acquired glycopeptide resistance in Enterococcus faecalis BM4405 [J].

Fines, M ;

Perichon, B ;

Reynolds, P ;

Sahm, DF ;

Courvalin, P .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1999, 43 (09) :2161-2164