A CDE/CHR tandem element regulates cell cycle-dependent repression of cyclin B2 transcription

被引：51

作者：

Dohna, CLZ

Brandeis, M

Berr, F

Mössner, J

Engeland, K

机构：

[1] Univ Leipzig, Dept Internal Med, Med Klin 2, Max Burger Res Ctr, D-04103 Leipzig, Germany

[2] Hebrew Univ Jerusalem, Dept Genet, Silverman Life Sci Inst, IL-91904 Jerusalem, Israel

来源：

FEBS LETTERS | 2000年 / 484卷 / 02期

关键词：

cell cycle; CDE; CHR; E2F; transcriptional repression; cancer;

D O I：

10.1016/S0014-5793(00)02133-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cyclin B is an important regulator of progression through the cell division cycle. The oscillating appearance of cyclin B1 and BZ proteins during the cell cycle is in part due to fluctuating mRNA levels. We had identified earlier a tandem promoter element named cell cycle-dependent element (CDE) and cell cycle genes homology region (CHR) which regulates cell cycle-dependent transcription of cdc25C, cyclin A and cdc2. Here we describe that cyclin BZ transcription is repressed through a novel CDE/CHR clement in resting and G(1) cells. By relief of this repression in S and G(2) oscillating expression of cyclin B2 mRNA is achieved during the cell cycle. (C) 2000 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

引用

页码：77 / 81

页数：5

共 31 条

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