MRI Measures of Alzheimer's Disease and the AddNeuroMed Study

被引：114

作者：

Simmons, Andrew ^{[1
,2
,3
,4
]}

Westman, Eric ^{[5
]}

Muehlboeck, Sebastian ^{[6
]}

Mecocci, Patrizia ^{[7
]}

Vellas, Bruno ^{[8
]}

Tsolaki, Magda ^{[9
]}

Kloszewska, Iwona ^{[10
]}

Wahlund, Lars-Olof ^{[5
]}

Soininen, Hilkka ^{[11
,12
]}

Lovestone, Simon ^{[2
,3
,4
]}

Evans, Alan ^{[6
]}

Spenger, Christian ^{[13
]}

机构：

[1] Kings Coll London, Ctr Neuroimaging Sci, Inst Psychiat, London SE5 8AF, England

[2] Maudsley NHS Fdn Trust, London, England

[3] Kings Coll London, MRC Ctr Neurodegenerat, Inst Psychiat, London SE5 8AF, England

[4] NIHR Specialist Biomed Res Ctr Mental Hlth S Lond, London, England

[5] Karolinska Inst, Sect Clin Geriatr, Dept Neurobiol Care Sci & Soc, Stockholm, Sweden

[6] McGill Univ, Montreal Neurol Inst, Montreal, PQ, Canada

[7] Univ Perugia, Inst Gerontol & Geriatr, I-06100 Perugia, Italy

[8] Univ Toulouse 3, Toulouse Gerontopole Univ Hosp, INSERM, U558, F-31062 Toulouse, France

[9] Aristotle Univ Thessaloniki, GR-54006 Thessaloniki, Greece

[10] Med Univ Lodz, Lodz, Poland

[11] Kuopio Univ Hosp, SF-70210 Kuopio, Finland

[12] Univ Kuopio, Dept Neurol, Kuopio, Finland

[13] Karolinska Inst, Dept Clin Sci Intervent & Technol, Stockholm, Sweden

来源：

BIOMARKERS IN BRAIN DISEASE | 2009年 / 1180卷

关键词：

Alzheimer's disease (AD); mild cognitive impairment (MCI); magnetic resonance imaging (MRI); AddNeuroMed; InnoMed; CLASSIFICATION;

D O I：

10.1111/j.1749-6632.2009.05063.x

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Here we describe the AddNeuroMed multicenter magnetic resonance imaging (MRI) study for longitudinal assessment in Alzheimer's disease (AD). The study is similar to a faux clinical trial and has been established to assess longitudinal MRI changes in AD, mild cognitive impairment (MCI), and healthy control subjects using an image acquisition protocol compatible with the Alzheimer's Disease Neuroimaging Initiative (ADNI). The approach consists of a harmonized MRI acquisition protocol across centers, rigorous quality control, a central data analysis hub, and an automated image analysis pipeline. Comprehensive quality control measures have been established throughout the study. An intelligent web-accessible database holds details on both the raw images and data processed using a sophisticated image analysis pipeline. A total of 378 subjects were recruited (130 AD, 131 MCI, 117 healthy controls) of which a high percentage (97.3%) of the T1-weighted volumes passed the quality control criteria. Measurements of normalized whole brain volume, whole brain cortical thickness, and point-by-point group-based cortical thickness measurements, demonstrating the power of the automated image analysis techniques employed, are reported.

引用

页码：47 / 55

页数：9

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