Epoxide derivatives of pipecolic acid and proline are inhibitors of pipecolate oxidase

被引：33

作者：

Ho, B ^{[1
]}

Zabriskie, TM ^{[1
]}

机构：

[1] Oregon State Univ, Coll Pharm, Corvallis, OR 97331 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 07期

关键词：

D O I：

10.1016/S0960-894X(98)00106-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The cis-4,5-epoxide derivative of L-pipecolic acid (2S,4S,5R-epoxypipecolic acid, cis-3) was synthesized and found to serve as an excellent substrate for L-pipecolate oxidase (L-PO) and also to cause time-dependent, irreversible inactivation of the enzyme. Data are presented showing this compound is a mechanism-based inhibitor of L-PO, whereas 2S,3R,4S-epoxyproline acts as a reversible inhibitor. (C) 1998 Elsevier Science Ltd. All rights reserved.

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页码：739 / 744

页数：6

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