Inhibition of cyclooxygenase-2 improves cardiac function in myocardial infarction

被引：61

作者：

Saito, T

Rodger, IW

Hu, F

Shennib, H

Giaid, A

机构：

[1] Montreal Gen Hosp, Dept Pathol, Montreal, PQ H3G 1A4, Canada

[2] Montreal Gen Hosp, Dept Med, Montreal, PQ H3G 1A4, Canada

[3] McGill Univ, Montreal, PQ, Canada

[4] Continuum Heart Inst, Ctr Innovat Cardiovasc Therapy, New York, NY USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2000年 / 273卷 / 02期

基金：

英国医学研究理事会;

关键词：

cyclooxygenase-2; myocardial infarction; selective COX-2 inhibitor; rat;

D O I：

10.1006/bbrc.2000.3010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Induction of cyclooxygenase-a (COX-2) in ischemic myocardium is thought to increase the production of proinflammatory prostanoids and contribute significantly to the ischemic inflammation. Left ventricular myocardial infarction (MI) was created by ligating the left coronary artery in Lewis rats. Hemodynamic measurements at 4 weeks showed better cardiac function in the group treated with a selective COX-2 inhibitor (DFU; 5 mg/kg/day) for 2 weeks after induction of MI compared to the vehicle treated group. These results suggest that induction of COX-2 contributes to myocardial dysfunction, and that selective inhibition of COX-2 could constitute an important therapeutic target for the treatment of MI. (C) 2000 Academic Press.

引用

页码：772 / 775

页数：4

共 21 条

[1] Modulation of oxidant status by meloxicam in experimentally induced arthritis [J].